原著論文
2023年
- ESS2 controls prostate cancer progression through recruitment of chromodomain helicase DNA binding protein 1.
Takahashi S, Takada I, Hashimoto K, Yokoyama A, Nakagawa T, Makishima M, Kume H.
Sci Rep. 2023 Jul 31;13(1):12355. - Postnatal expression of CD38 in astrocytes regulates synapse formation and adult social memory.
Hattori T, Cherepanov SM, Sakaga R, Roboon J, Nguyen DT, Ishii H, Takarada-Iemata M, Nishiuchi T, Kannon T, Hosomichi K, Tajima A, Yamamoto Y, Okamoto H, Sugawara A, Higashida H, Hori O.
EMBO J. 2023 Aug 1;42(15):e111247. - Primary aldosteronism and obstructive sleep apnea: the strong ties between them.
Akira Sugawara, Hiroki Shimada, Yuri Otsubo, Takumi Kouketsu, Atsushi Yokoyama.
Hypertens Res. 2023 Jul;46(7):1712-1713.
2022年
- YM750, an ACAT Inhibitor, Acts on Adrenocortical Cells to Inhibit Aldosterone Secretion Due to Depolarization.
Shimada H, Hata S, Yamazaki Y, Otsubo Y, Sato I, Ise K, Yokoyama A, Suzuki T, Sasano H, Sugawara A, Nakamura Y.
Int J Mol Sci. 2022 Oct 24;23(21):12803. - Transcriptional coregulator Ess2 controls survival of post-thymic CD4+ T cells through the Myc and IL-7 signaling pathways.
Takada I, Hidano S, Takahashi S, Yanaka K, Ogawa H, Tsuchiya M, Yokoyama A, Sato S, Ochi H, Nakagawa T, Kobayashi T, Nakagawa S, Makishima M.
J Biol Chem. 2022 Aug 3:102342.
- IRF2BP2 is a novel HNF4α co-repressor: Its role in gluconeogenic gene regulation via biochemically labile interaction.
Kouketsu T, Monma R, Miyairi Y, Sawatsubashi S, Shima H, Igarashi K, Sugawara A, Yokoyama A.
Biochem Biophys Res Commun. 2022 May 18;615:81-87.
- Expression of p11 and heteromeric TASK channels in mouse adrenal cortical cells and H295R cells.
Matsuoka H, Harada K, Sugawara A, Kim D, Inoue M.
Acta Histochem. 2022 Jul;124(5):151898.
- The physiological and pathophysiological roles of carbohydrate response element binding protein in the kidney.
Yokoyama A, Suzuki S, Okamoto K, Sugawara A.
Endocr J. 2022 Jun 28;69(6):605-612.
- PCA3 controls chromatin organization and p53 signal activation by regulating LAP2α-lamin A complexes.
Ito S, Ueda T, Yokoyama A, Fujihara A, Hongo F, Ukimura O.
Cancer Gene Ther. 2022 Mar;29(3-4):358-368.
- A novel 8.57-kb deletion of the upstream region of PRKAR1A in a family with Carney complex.
Ito S, Hashimoto A, Yamaguchi K, Kawamura S, Myoen S, Ogawa M, Sato I, Minato T, Miyabe S, Nakazato A, Fujii K, Mochizuki M, Fujimori H, Tamai K, Niihori T, Aoki Y, Sugawara A, Sasano H, Shima H, Yasuda J.
Mol Genet Genomic Med. 2022 Feb 6:e1884.
2021年
- Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP1.
Yokoyama A, Kouketsu T, Otsubo Y, Noro E, Sawatsubashi S, Shima H, Satoh I, Kawamura S, Suzuki T, Igarashi K, Sugawara A.
J Endocr Soc. 2021 Sep 13;5(11):bvab150.
- Comparative proteomic analysis to identify the novel target gene of angiotensin II in adrenocortical H295R cells.
Ito R, Shima H, Masuda K, Sato I, Shimada H, Yokoyama A, Shirahige K, Igarashi K, Sugawara A.
Endocr J. 2021 Apr 28;68(4):441-450.
- Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway.
Shimada H, Yamazaki Y, Sugawara A, Sasano H, Nakamura Y.
Biomedicines. 2021 Jul 26;9(8):892. - The usefulness of angiotensin-(1-7) and des-Arg9-bradykinin as novel biomarkers for metabolic syndrome.
Sugawara A, Shimada H, Otsubo Y, Kouketsu T, Suzuki S, Yokoyama A.
Hypertens Res. 2021 Aug;44(8):1034-1036.
- Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4.
Sakakibara I, Yanagihara Y, Himori K, Yamada T, Sakai H, Sawada Y, Takahashi H, Saeki N, Hirakawa H, Yokoyama A, Fukada SI, Sawasaki T, Imai Y.
iScience. 2021 Mar 13;24(4):102303.
- Discovery of a chemical compound that suppresses expression of BEX2, a dormant cancer stem cell-related protein.
Saijoh S, Nakamura-Shima M, Shibuya-Takahashi R, Ito R, Sugawara A, Yamazaki T, Imai T, Asada Y, Matsuura K, Iwai W, Wakui Y, Abue M, Kawamura S, Katayose Y, Fujimori H, Mochizuki M, Yasuda J, Yamaguchi K, Sugamura K, Satoh K, Katori Y, Tamai K.
Biochem Biophys Res Commun. 2021 Jan 22;537:132-139.
- The establishment of a novel high-throughput screening system using RNA-guided genome editing to identify chemicals that suppress aldosterone synthase expression.
Ito R, Morita M, Nakano T, Sato I, Yokoyama A, Sugawara A.
Biochem Biophys Res Commun. 2021 Jan 1;534:672-679.
2020年
- FABP7 Regulates Acetyl-CoA Metabolism Through the Interaction with ACLY in the Nucleus of Astrocytes.
Kagawa Y, Umaru BA, Shima H, Ito R, Zama R, Islam A, Kanno SI, Yasui A, Sato S, Jozaki K, Shil SK, Miyazaki H, Kobayashi S, Yamamoto Y, Kogo H, Shimamoto-Mitsuyama C, Sugawara A, Sugino N, Kanamori M, Tominaga T, Yoshikawa T, Fukunaga K, Igarashi K, Owada Y.
Mol Neurobiol. 2020 Dec;57(12):4891-4910.
- CEP131 Abrogates CHK1 Inhibitor-Induced Replication Defects and Is Associated with Unfavorable Outcome in Neuroblastoma.
Ando K, Cázares-Ordoñez V, Makishima M, Yokoyama A, Suenaga Y, Nagase H, Kobayashi S, Kamijo T, Koshinaga T, Wada S.
J Oncol. 2020 Sep 15;2020:2752417.
- Expression and pathophysiological significance of carbohydrate response element binding protein (ChREBP) in the renal tubules of diabetic kidney.
Suzuki S, Yokoyama A, Noro E, Aoki S, Shimizu K, Shimada H, Sugawara A.
Endocr J. 2020 Mar 28;67(3):335-345.
- Effects of Adipocyte-derived Factors on the Adrenal Cortex.
Shimada H, Noro E, Suzuki S, Sakamoto J, Sato I, Parvin R, Yokoyama A, Sugawara A.
Curr Mol Pharmacol. 2020;13(1):2-6.
2019年
- Long-term assessment of intrarenal blood flow with Doppler ultrasonography for hypertensive patients after percutaneous transluminal renal angioplasty.
Abe M, Araya K, Akaishi T, Miki T, Miki M, Sugawara A, Abe T, Ishii T, Ito S.
Hypertens Res. 2019 Oct;42(10):1649-1651.
- O-linked β-N-acetylglucosamine transferase is involved in pro-opiomelanocortin gene expression in mouse pituitary corticotroph AtT-20 cells.
Makita K, Takayasu S, Usutani M, Nakada-Nakayama Y, Kageyama K, Sugawara A, Daimon M.
Neurosci Lett. 2019 Oct 15;711:134407.
- Deletion of CD38 Suppresses Glial Activation and Neuroinflammation in a Mouse Model of Demyelination.
Roboon J, Hattori T, Ishii H, Takarada-Iemata M, Le TM, Shiraishi Y, Ozaki N, Yamamoto Y, Sugawara A, Okamoto H, Higashida H, Kitao Y, Hori O.
Front Cell Neurosci. 2019 Jun 6;13:258.
- Transglutaminase-mediated cross-linking of WDR54 regulates EGF receptor-signaling.
Maeda A, Nishino T, Matsunaga R, Yokoyama A, Suga H, Yagi T, Konishi H.
Biochim Biophys Acta Mol Cell Res. 2019 Feb;1866(2):285-295.
- Partial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit.
Sato K, Ito H, Yokoyama A, Toba G, Yamamoto D.
Nat Commun. 2019 Jan 11;10(1):166.
2018年
- Crucial role of Reg I from acinar-like cell cluster touching with islets (ATLANTIS) on mitogenesis of beta cells in EMC virus-induced diabetic mice.
Aida K, Kobayashi T, Takeshita A, Jimbo E, Nishida Y, Yagihashi S, Hosoi M, Fukui T, Sugawara A, Takasawa S.
Biochem Biophys Res Commun. 2018 Sep 5;503(2):963-969.
- Inhibitory Effects of a Novel PPAR-gamma Agonist MEKT1 on Pomc Expression/ACTH Secretion in AtT20 Cells.
Parvin R, Noro E, Saito-Hakoda A, Shimada H, Suzuki S, Shimizu K, Miyachi H, Yokoyama A, Sugawara A.
PPAR Res. 2018 Apr 23;2018:5346272.
- Endogenous Purification of NR4A2 (Nurr1) Identified Poly(ADP-Ribose) Polymerase 1 as a Prime Coregulator in Human Adrenocortical H295R Cells.
Noro E, Yokoyama A, Kobayashi M, Shimada H, Suzuki S, Hosokawa M, Takehara T, Parvin R, Shima H, Igarashi K, Sugawara A.
Int J Mol Sci. 2018 May 8;19(5):1406.
- Heparan sulfate in pancreatic β-cells contributes to normal glucose homeostasis by regulating insulin secretion.
Matsuzawa T, Yoshikawa T, Iida T, Kárpáti A, Kitano H, Harada R, Nakamura T, Sugawara A, Yamaguchi Y, Yanai K.
Biochem Biophys Res Commun. 2018 May 15;499(3):688-695.
- The reduction of heparan sulphate in the glomerular basement membrane does not augment urinary albumin excretion.
Aoki S, Saito-Hakoda A, Yoshikawa T, Shimizu K, Kisu K, Suzuki S, Takagi K, Mizumoto S, Yamada S, van Kuppevelt TH, Yokoyama A, Matsusaka T, Sato H, Ito S, Sugawara A.
Nephrol Dial Transplant. 2018 Jan 1;33(1):26-33. - Time and dose-dependent effects of dexamethasone on Pttg expression in AtT20 cells.
Parvin R, Sugawara A.
Barishal University J. 2018; 5, 235-247.
2017年
- Biochemical Analysis of Histone Succinylation.
Yokoyama A, Katsura S, Sugawara A.
Biochem Res Int. 2017;2017:8529404.
- High glucose stimulates expression of aldosterone synthase (CYP11B2) and secretion of aldosterone in human adrenal cells.
Shimada H, Kogure N, Noro E, Kudo M, Sugawara K, Sato I, Shimizu K, Kobayashi M, Suzuki D, Parvin R, Saito-Ito T, Uruno A, Saito-Hakoda A, Rainey WE, Ito S, Yokoyama A, Sugawara A.
FEBS Open Bio. 2017 Aug 29;7(9):1410-1421.
- Suppressive effects of RXR agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion and blood pressure.
Suzuki D, Saito-Hakoda A, Ito R, Shimizu K, Parvin R, Shimada H, Noro E, Suzuki S, Fujiwara I, Kagechika H, Rainey WE, Kure S, Ito S, Yokoyama A, Sugawara A.
PLoS One. 2017 Aug 11;12(8):e0181055.
- A ubiquitin-proteasome inhibitor bortezomib suppresses the expression of CYP11B2, a key enzyme of aldosterone synthesis.
Ito R, Sato I, Tsujita T, Yokoyama A, Sugawara A.
Biochem Biophys Res Commun. 2017 Jul 15;489(1):21-28.
- Effects of Retinoids on Vasculatures.
Parvin R, Saito-Hakoda-A, Suzuki S, Noro E, Shimada H, Yokoyama A, Sugawara A.
J Endocrinol Thyroid Res, 2017 Jul, vol. 2, No. 3, 1-5.
- Role of NeuroD1 on the negative regulation of Pomc expression by glucocorticoid.
Parvin R, Saito-Hakoda A, Shimada H, Shimizu K, Noro E, Iwasaki Y, Fujiwara K, Yokoyama A, Sugawara A.
PLoS One. 2017 Apr 13;12(4):e0175435.
2016年
- Diagnosis and treatment of adrenal insufficiency including adrenal crisis: a Japan Endocrine Society clinical practice guideline [Opinion].
Yanase T, Tajima T, Katabami T, Iwasaki Y, Tanahashi Y, Sugawara A, Hasegawa T, Mune T, Oki Y, Nakagawa Y, Miyamura N, Shimizu C, Otsuki M, Nomura M, Akehi Y, Tanabe M, Kasayama S.
Endocr J. 2016 Sep 30;63(9):765-784.
- Hydroxylation of methylated DNA by TET1 in chondrocyte differentiation of C3H10T1/2 cells.
Ito R, Shimada H, Yazawa K, Sato I, Imai Y, Sugawara A, Yokoyama A.
Biochem Biophys Rep. 2016 Mar;5:134-140.
- Versatile function of the circadian protein CIPC as a regulator of Erk activation.
Matsunaga R, Nishino T, Yokoyama A, Nakashima A, Kikkawa U, Konishi H.
Biochem Biophys Res Commun. 2016 Jan 15;469(3):377-83.
2015年
- Effects of RXR Agonists on Cell Proliferation/Apoptosis and ACTH Secretion/Pomc Expression.
Saito-Hakoda A, Uruno A, Yokoyama A, Shimizu K, Parvin R, Kudo M, Saito-Ito T, Sato I, Kogure N, Suzuki D, Shimada H, Yoshikawa T, Fujiwara I, Kagechika H, Iwasaki Y, Kure S, Ito S, Sugawara A.
PLoS One. 2015 Dec 29;10(12):e0141960.
2014年
- Role of histamine H3 receptor in glucagon-secreting αTC1.6 cells.
Nakamura T, Yoshikawa T, Naganuma F, Mohsen A, Iida T, Miura Y, Sugawara A, Yanai K.
FEBS Open Bio. 2014 Dec 13;5:36-41.
- Retinoic acid receptor-alpha up-regulates proopiomelanocortin gene expression in AtT20 corticotroph cells.
Uruno A, Saito-Hakoda A, Yokoyama A, Kogure N, Matsuda K, Parvin R, Shimizu K, Sato I, Kudo M, Yoshikawa T, Kagechika H, Iwasaki Y, Ito S, Sugawara A. Endocr J. 2014;61(11):1105-14.
- Identification of Posttranslational Modifications in Peroxisome Proliferator-Activated Receptor γ Using Mass Spectrometry.
Katsura S, Okumura T, Ito R, Sugawara A, Yokoyama A.
PPAR Res. 2014;2014:468925.
- Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex.
Yokoyama A, Igarashi K, Sato T, Takagi K, Otsuka I M, Shishido Y, Baba T, Ito R, Kanno J, Ohkawa Y, Morohashi K, Sugawara A.
J Biol Chem. 2014 Jun 27;289(26):18152-62 - Aberrant gonadotropin-releasing hormone receptor (GnRHR) expression and its regulation of CYP11B2 expression and aldosterone production in adrenal aldosterone-producing adenoma (APA).
Nakamura Y, Hattangady NG, Ye P, Satoh F, Morimoto R, Ito-Saito T, Sugawara A, Ohba K, Takahashi K, Rainey WE, Sasano H.
Mol Cell Endocrinol. 2014 Mar 25;384(1-2):102-8.
- Angiotensin II receptor blockers differentially affect CYP11B2 expression in human adrenal H295R cells.
Matsuda K, Uruno A, Kogure N, Sugawara K, Shimada H, Nezu M, Saito-Ito T, Iki Y, Kudo M, Shimizu K, Sato I, Yoshikawa T, Satoh F, Ito R, Yokoyama A, Rainey WE, Saito-Hakoda A, Ito S, Sugawara A.
Mol Cell Endocrinol. 2014 Mar 5;383(1-2):60-8.
- PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues.
Felizola SJ, Nakamura Y, Ono Y, Kitamura K, Kikuchi K, Onodera Y, Ise K, Takase K, Sugawara A, Hattangady N, Rainey WE, Satoh F, Sasano H.
J Mol Endocrinol. 2014 Feb 24;52(2):159-67.
- ARB affects nicotine-induced gene expression profile in human coronary artery endothelial cells.
Kudo M, Matsuda K, Sugawara K, Iki Y, Kogure N, Saito-Ito T, Shimizu K, Sato I, Yoshikawa T, Uruno A, Yokoyama A, Saito-Hakoda A, Ito S, Sugawara A.
World Journal of Hypertension. 2014 Feb; 4(1): 7-14.
- Nrf2 protects pancreatic beta-cells from oxidative and nitrosative stress in diabetic model mice.
Yagishita Y, Fukutomi T, Sugawara A, Kawamura H, Takahashi T, Pi J, Uruno A, Yamamoto M.
Diabetes. 2014 Feb;63(2):605-18.
- TET3-OGT interaction increases the stability and the presence of OGT in chromatin.
Ito R, Katsura S, Shimada H, Tsuchiya H, Hada M, Okumura T, Sugawara A, Yokoyama A.
Genes Cells. 2014 Jan;19(1):52-65.
- The expression and function of histamine H₃ receptors in pancreatic beta cells.
Nakamura T, Yoshikawa T, Noguchi N, Sugawara A, Kasajima A, Sasano H, Yanai K.
Br J Pharmacol. 2014 Jan;171(1):171-85.
2013年
- The Keap1-Nrf2 system prevents onset of diabetes mellitus.
Uruno A, Furusawa Y, Yagishita Y, Fukutomi T, Muramatsu H, Negishi T, Sugawara A, Kensler TW, Yamamoto M.
Mol Cell Biol. 2013 Aug;33(15):2996-3010.
- A comparative study of thyroid hormone and lipid status of patient with and without diabetes in adults.
Saha HR, Khan H, Sarkar BC, Khan SA, Sana NK, Sugawara A, Choudhury S.
OJEMD. 2013; 3: 113-119.
2012年
- Identification of a major enzyme for the synthesis and hydrolysis of cyclic ADP-ribose in amphibian cells and evolutional conservation of the enzyme from human to invertebrate.
Ikeda T, Takasawa S, Noguchi N, Nata K, Yamauchi A, Takahashi I, Yoshikawa T, Sugawara A, Yonekura H, Okamoto H.
Mol Cell Biochem. 2012 Jul;366(1-2):69-80.
- Assisting the diagnosis of overt hypothyroidism with pattern recognition methods, making use of a set of routine tests, and their multiple correlation with total T4.
Aoki S, Hoshi K, Kawakami J, Sato K, Sato W, Satoh K, Mori K, Sugawara A, Nakagawa Y, Yoshida K.
Biomed Pharmacother. 2012 Apr;66(3):195-205.
2011年
- Transfection of endothelial nitric oxide synthase gene improves angiogenic efficacy of endothelial progenitor cells in rabbits with hindlimb ischemia.
Kaur S, Harikrishnan VS, Shenoy SJ, Radhakrishna NS, Uruno A, Sugawara A, Kartha CC.
J Clinic Experiment Cardiol. 2011; 2:140.
- Retinoid receptors in human esophageal squamous cell carcinoma: retinoid X receptor as a potent prognostic factor.
Fujishima F, Suzuki T, Nakamura Y, Taniyama Y, Ono K, Sugawara A, Miyazaki S, Moriya T, Sato A, Satomi S, Sasano H.
Pathol Int. 2011 Jul;61(7):401-8.
- The expression of REG 1A and REG 1B is increased during acute amebic colitis.
Peterson KM, Guo X, Elkahloun AG, Mondal D, Bardhan PK, Sugawara A, Duggal P, Haque R, Petri WA Jr.
Parasitol Int. 2011 Sep;60(3):296-300.
- All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta.
Uruno A, Noguchi N, Matsuda K, Nata K, Yoshikawa T, Chikamatsu Y, Kagechika H, Harigae H, Ito S, Okamoto H, Sugawara A.
J Leukoc Biol. 2011 Aug;90(2):235-47.
- Expression profile of the REG gene family in colorectal carcinoma.
Zheng HC, Sugawara A, Okamoto H, Takasawa S, Takahashi H, Masuda S, Takano Y.
J Histochem Cytochem. 2011 Jan;59(1):106-15.
- Peroxisome proliferator-activated receptor-{gamma} suppresses CYP11B2 expression and aldosterone production.
Uruno A, Matsuda K, Noguchi N, Yoshikawa T, Kudo M, Satoh F, Rainey WE, Hui XG, Akahira J, Nakamura Y, Sasano H, Okamoto H, Ito S, Sugawara A.
J Mol Endocrinol. 2011 Jan 19;46(1):37-49.
- Assisting the diagnosis of Graves’ hyperthyroidism with pattern recognition methods and a set of three routine tests parameters, and their correlations with free T4 levels: Extension to male patients.
Aoki S, Hoshi K, Kawakami J, Sato K, Satoh K, Mori K, Sugawara A, Saito Y, Yoshida K.
Biomed Pharmacother. 2011 Mar;65(2):95-104.